Procoagulation factors

• Physiological process in which bleeding is stopped.
• vasoconstriction to slow bleeding.
• B. Platelets bind to collagen & formation of temporary hemostatic plug.
•
• C. Local activation of the
• coagulation cascade - involving endothelial tissue factor & platelet phospholipids - results in fibrin polymerization, formation of secondary hemostatic plug.
• D. Fibrinolysis.
• We will concentrate on the third stage of hemostasis-
• The coagulation process .
• The coagulation process is controlled by many substances that promote clotting , these are the - procoagulation factors.
• Each of the procoagulation factors is identified by Roman numerals and perform a specific step in the coagulation process.
• The activation of one procoagulation factor/ proenzyme is designed to activate the next factor in the sequence – a cascade effect.
• Most of the procoagulation factors are present in blood at all times, this way the multistep process ensures that a massive episode of intravascular clotting will not occur by chance.
• The procoagulation factors
• Factor
• Trivial Name
• Pathway
• Function
• I
• Fibrinogen
• Both
• Cleaved by thrombin to form fibrin clot
• II
• Prothrombin
• Both
• Activated on surface of activated platelets by prothrombinase complex
• III
• Tissue thromboplastin
• Extrinsic
• A subendothelial cell-surface glycoprotein that acts as a cofactor for factor VII
• IV
• Calcium
• Both
•
• V
• Proaccelerin
• Both
•
• VI (Va)
• Accelerin
• -
•
• VII
• Proconvertin
• Extrinsic
•
• * von Willebrand factor - associated with subendothelial connective tissue, serves as a bridge between platelet glycoproteins and the collagen of the blood vessel.
• Factor
• Trivial Name
• Pathway
• Function
• VIII
• Antihemophiliac factor A, antihemophilic globulin (AHG)
• Intrinsic
•
• IX
• Christmas Factor, antihemophilic factor B
• Intrinsic
•
• X
• Stuart-Prower Factor
• Both
• Activated on surface of activated platelets
• XI
• Plasma thromboplastin antecedent (PTA)
• Intrinsic
•
• XII
• Hageman Factor
• Intrinsic
• Binds to exposed collagen at site of vessel wall injury
• XIII
• Fibrin stabilizing factor (FSF)
• Both
• Stabilizes fibrin clot by covalent cross-linking
• Synthesis of procoagulation factors:
•...

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